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Unnisa, Kouser
- Design, Synthesis and Characterisation of Novel Carbazole Linked Propeonones
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, IN
1 Department of Pharmaceutical Chemistry, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 3 (2017), Pagination: 271-274Abstract
Natural products derived from plants or microbes play a major role in drug discovery as a source of original bioactive structures and offer models for rational drug design. The promising natural anti-mycobacterials include carbazole alkaloids, such as Clausine and Micromeline isolated independently from several sources and were shown to have potent antitubercular activity. In recent years, carbazole alkaloids are playing important role in discovering new antitubercular leads against non-resistant and multi-drug resistant strains of M. tuberculosis. Few among them are 7-hydroxymukonal (IX, MIC 25lg/mL), Clausine K (MIC: 100lg/mL), and Micromeline (MIC: 31.5lg/mL). Knölker screened a series of carbazole alkaloids for their in vitro anti-TB activity. It appeared that anti-TB activity is highly sensitive to subtle changes in substitution around the carbazole ring system. Herein we report the synthesis of Nine Novel Carbazole linked propeonones in excellent yields via N-Methylation of Carbazole followed by Friedel's crafts acylation of N-methyl carbazole. All the compounds were characterised by Spectroscopic methods.Keywords
Carbazole Alkaloids, Anti-TB Activity, Carbazole Linked Propeonones and N-Methylation.- Anti Obesity Activity of Rhynchosia beddomei by Using Progesteron Induced Obesity in Mice, and Mono Sodium Glutamate Induced Obesity in Rats
Abstract Views :646 |
PDF Views:6
Authors
Affiliations
1 Department of Pharmacology, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, IN
1 Department of Pharmacology, Azad College of Pharmacy, Moinabad-Chilkur Road, Hyderabad-500075, IN